| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
CCAR1 Blocking Peptide for STJ500386 is synthetically produced from the 645-695 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
CCAR1 |
| Gene ID: |
55749 |
| Uniprot ID: |
CCAR1_HUMAN |
| Immunogen Region: |
645-695 |
| Specificity: |
This blocking peptide is recommended for use in combination with CCAR1 antibody, STJ500386 |
| Immunogen: |
Synthetic peptide taken within amino acid region 645-695 on human Cell division cycle and apoptosis regulator protein 1. |
| Tissue Specificity | Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors. |
| Function | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells. |
| Peptide Name | Cell Division Cycle And Apoptosis Regulator Protein 1Cell Cycle And Apoptosis Regulatory Protein 1Carp-1Death Inducer With Sap Domain |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Peptide Names | Cell Division Cycle And Apoptosis Regulator Protein 1 proteinCell Cycle And Apoptosis Regulatory Protein 1 proteinCarp-1 proteinDeath Inducer With Sap Domain proteinCCAR1 proteinCARP1 proteinDIS protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
