| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
CACNB2 Positive Control for STJ502190 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Cacnb2 |
| Gene ID: |
116600 |
| Uniprot ID: |
CACB2_RAT |
| Specificity: |
This is positive control is recommended for use in combination with CACNB2 antibody STJ502190. |
| Tissue Specificity | Highly expressed in heart and brain, and at lower levels in lung. |
| Post Translational Modifications | Regulated through phosphorylation at Thr-549 by CaMK2D. |
| Function | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current. Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition. May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C. |
| Peptide Name | Voltage-Dependent L-Type Calcium Channel Subunit Beta-2Cab2Calcium Channel Voltage-Dependent Subunit Beta 2 |
| Database Links | Reactome: R-RNO-112308Reactome: -RNO-422356Reactome: -RNO-5576892Reactome: -RNO-5576893 |
| Cellular Localisation | Cell MembraneSarcolemmaPeripheral Membrane ProteinCytoplasmic Side |
| Alternative Peptide Names | Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 proteinCab2 proteinCalcium Channel Voltage-Dependent Subunit Beta 2 proteinCacnb2 proteinCacnlb2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
