| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
BMP1 Positive Control for STJ500266 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
BMP1 |
| Gene ID: |
649 |
| Uniprot ID: |
BMP1_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with BMP1 antibody STJ500266. |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion. |
| Function | Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. Isoform BMP1-3: Plays an important role in bone repair by acting as a coactivator of BMP7. |
| Peptide Name | Bone Morphogenetic Protein 1Bmp-1Mammalian Tolloid ProteinMtldProcollagen C-ProteinasePcp |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-1650814Reactome: R-HSA-2214320Reactome: R-HSA-2243919Reactome: R-HSA-8963896 P13497-3 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkSecretedExtracellular SpaceExtracellular MatrixCo-Localizes With Postn In The GolgiIsoform Bmp1-3: Secreted |
| Alternative Peptide Names | Bone Morphogenetic Protein 1 proteinBmp-1 proteinMammalian Tolloid Protein proteinMtld proteinProcollagen C-Proteinase proteinPcp proteinBMP1 proteinPCOLC protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
