BMP1 Blocking Peptide for STJ500268 is synthetically produced from the 680-730 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 680-730 on human BMP1 protein.
Immunogen Region
680-730
Specificity
This blocking peptide is recommended for use in combination with BMP1 antibody, STJ500268
Additional Info
Tissue Specificity
Ubiquitous.
Post Translational Modifications
Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion.
Function
Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. Isoform BMP1-3: Plays an important role in bone repair by acting as a coactivator of BMP7.
Peptide Name
Bone Morphogenetic Protein 1Bmp-1Mammalian Tolloid ProteinMtldProcollagen C-ProteinasePcp
Golgi ApparatusTrans-Golgi NetworkSecretedExtracellular SpaceExtracellular MatrixCo-Localizes With Postn In The GolgiIsoform Bmp1-3: Secreted
Alternative Peptide Names
Bone Morphogenetic Protein 1 proteinBmp-1 proteinMammalian Tolloid Protein proteinMtld proteinProcollagen C-Proteinase proteinPcp proteinBMP1 proteinPCOLC protein
