Posted by M.Popov on 12th Nov 2020
Trial size DAB1 antibodies available in the Antibody Validation Project
Trial size DAB1 antibodies available in the Antibody Validation Project
Introduction:
DAB adaptor protein 1 is a protein synthesised from the DAB1 gene and is responsible for normal brain development and is thought to be a signal transducer interacting with protein kinase pathways. Additionally, DAB1 can mainly be found in the cerebellum and MAIT T-cells and mutations of it can lead to several forms of ataxia and the Marinesco-Sjgren Syndrome. We provide a number of trial sized antibodies, which are suitable for DAB1 research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding DAB1 that we have provided in the links below.
- What is DAB1?
- Where is DAB1 found?
- What role does DAB1 play in disease?
- DAB1 antibodies in the Antibody Validation project
- Customer reviewed DAB1 antibodies
- Other DAB1 antibodies available in the Antibody Validation Project
- Popular DAB1 antibodies not currently in the Antibody Validation Project
- How does the Antibody Validation Project work?
What is DAB1?
DAB1 is a protein coding gene. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. For example in mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. The DAB1 gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain.
Where is DAB1 found?
DAB1 is usually found in the vesicles of the cells and is mainly found in the brain and intestine on tissue level. Inside the brain, it is enriched in the cerebellum and in the immune system it is expressed mainly in the MAIT T-cells.
What role does DAB1 play in disease?
Mutations of this gene are related to spinocerebellar ataxia 37, presenting progressive incoordination of the limbs, eyes and speech due to degeneration of the cerebellum.
DAB1 antibodies in the Antibody Validation project
St John's Laboratory offers a variety of trial size primary antibodies which target DAB1, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.
Customer reviewed DAB1 antibodies
| Model | Name | Host | Clonality | Rating | Application Tested |
|---|---|---|---|---|---|
| STJ90682 | Anti-Phospho-Dab1 (Y232) antibody | Rabbit | Polyclonal | 5 | IHC |
Other DAB1 antibodies available in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ90682 | Anti-Phospho-Dab1 (Y232) antibody | Rabbit | Polyclonal | ELISA,IF,IHC,WB |
| STJ92647 | Anti-Dab1 antibody | Rabbit | Polyclonal | WB,IF,ELISA |
Popular DAB1 antibodies not currently in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ112387 | Anti-DAB1 Antibody | Rabbit | Polyclonal | WB |
How does the Antibody Validation Project work?
In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.
The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.
Find out more here.