Posted by M.Popov on 12th Nov 2020
Trial size ARNT antibodies available in the Antibody Validation Project
Trial size ARNT antibodies available in the Antibody Validation Project
Introduction:
Aryl hydrocarbon receptor nuclear translocator(ARNT) gene provides the information for synthesising the ARNT protein, which is responsible for the normal functioning of the hypoxia response element and also functions as a transcriptional regulator of the adaptive response to hypoxia. Several mutations of it are present in low tissue specific cancers, and we provide a number of trial sized antibodies, which are suitable for ARNT research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding ARNT that we have provided in the links below.
- What is ARNT?
- Where is ARNT found?
- What role does ARNT play in disease?
- ARNT antibodies in the Antibody Validation project
- Customer reviewed ARNT antibodies
- Other ARNT antibodies available in the Antibody Validation Project
- Popular ARNT antibodies not currently in the Antibody Validation Project
- How does the Antibody Validation Project work?
What is ARNT?
The protein encoded by this gene is required for activity of the Ah (dioxin) receptor and for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription.
Where is ARNT found?
On intracellular level, the ARNT protein can be found in the nucleoplasm and the nuclear bodies. Inside the human organism, both the gene and the expressed protein have low tissue specificity and can be detected in all tissues.
What role does ARNT play in disease?
Because it is connected with the HRE, disruptions in the protein or gene can lead to bad responses to environmental stresses and inducing general or tissue hypoxia. Apart from that, several mutations have been found in human cancers, with low cancer specifity.
ARNT antibodies in the Antibody Validation project
St John's Laboratory offers a variety of trial size primary antibodies which target ARNT, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.
Customer reviewed ARNT antibodies
| Model | Name | Host | Clonality | Rating | Application Tested |
|---|---|---|---|---|---|
| STJ97602 | Anti-HIF-1 β/ARNT antibody | Mouse | Monoclonal | 4 | WB |
Other ARNT antibodies available in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ93499 | Anti-HIF- beta antibody | Rabbit | Polyclonal | WB,IHC,ELISA |
| STJ97377 | Anti-HIF- beta antibody | Rabbit | Polyclonal | WB,IHC |
| STJ97387 | Anti-HIF- beta antibody | Rabbit | Polyclonal | WB,IHC |
Popular ARNT antibodies not currently in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ116905 | Anti-ARNT Antibody | Rabbit | Polyclonal | WB |
| STJ22685 | Anti-ARNT Antibody | Rabbit | Polyclonal | WB,IHC |
| STJ73329 | Anti-ARNT Antibody | Goat | Polyclonal | ELISA,WB |
| STJ73330 | Anti-ARNT Antibody | Goat | Polyclonal | ELISA,WB |
How does the Antibody Validation Project work?
In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.
The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.
Find out more here.