Posted by M.Popov on 12th Nov 2020
Trial size ALK antibodies available in the Antibody Validation Project
Trial size ALK antibodies available in the Antibody Validation Project
Introduction:
Anaplastic lymphoma kinase(also known as ALK) is a gene encoding a receptor tyrosine kinase, part of the Insulin superfamily. It plays both a crucial role in developing the brain and nervous system in humans, but also alterations or mutations can lead to serious conditions such as lung cancer, neuroblastoma and others. We provide a number of trial sized antibodies, which are suitable for ALK research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding ALK that we have provided in the links below.
- What is ALK?
- Where is ALK found?
- What role does ALK play in disease?
- ALK antibodies in the Antibody Validation project
- Customer reviewed ALK antibodies
- Other ALK antibodies available in the Antibody Validation Project
- Popular ALK antibodies not currently in the Antibody Validation Project
- How does the Antibody Validation Project work?
What is ALK?
The ALK gene carries the information for a receptor tyrosine kinase, belonging to the Insulin receptor superfamily. It has an important role in brain development and normal function of the nervous system.
Where is ALK found?
In cells, ALK can be found primarily in the plasma membrane, cytoplasm ans nucleus. It is detected in many tissues, but higher concentrations are seen in the brain, pituitary gland and most abundantly in neurons.
What role does ALK play in disease?
ALK mutations, rearrangements and amplifications have been linked with several conditions, primarily series of tumours including neuroblastoma, non-small cell lung cancer and anaplastic large cell lymphomas. These are mainly the results of chromosomal rearrangements inside the gene, which is the most common genetic alteration of ALK.
ALK antibodies in the Antibody Validation project
St John's Laboratory offers a variety of trial size primary antibodies which target ALK, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.
Customer reviewed ALK antibodies
| Model | Name | Host | Clonality | Rating | Application Tested |
|---|---|---|---|---|---|
| STJ91562 | Anti-ALK antibody | Rabbit | Polyclonal | 5 | WB |
| STJ90845 | Anti-Phospho-ALK (Y1507) antibody | Rabbit | Polyclonal | 5 | WB |
Other ALK antibodies available in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ193212 | Anti-ALK (Phospho-Tyr1586) Antibody | Rabbit | Polyclonal | IHC,WB |
| STJ91196 | Anti-Phospho-ALK (Y1096) antibody | Rabbit | Polyclonal | IHC,ELISA |
| STJ91560 | Anti-ALK antibody | Rabbit | Polyclonal | WB,IHC,IF,ELISA |
| STJ91561 | Anti-ALK antibody | Rabbit | Polyclonal | IHC,ELISA |
Popular ALK antibodies not currently in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ110843 | Anti-Phospho-ALK-(Y1096) Antibody | Rabbit | Polyclonal | WB |
| STJ116404 | Anti-ALK Antibody | Rabbit | Polyclonal | WB,IHC |
| STJ180004 | Anti-ALK antibody | Mouse | Monoclonal | IHC |
| STJ180005 | Anti-ALK antibody | Rabbit | Monoclonal | IHC |
How does the Antibody Validation Project work?
In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.
The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.
Find out more here.