Biotinylated Mouse NECTIN4/PVRL4 protein (C-His-Avi) {Biotin} (STJP012878)
SPECIFICATIONS
HostMammalian Cells
ConjugationBiotin
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Biotinylated Mouse NECTIN4/PVRL4-C-His-Avi protein was developed from mammalian cells and has a target region of C-His-Avi. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 20mM PB, 100mM Arg-HCl, 10% Trehalose, 0.02% Tween 20, pH 7.5. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | Nectin4 |
| Gene ID | 71740 |
| Uniprot ID | NECT4_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Gly31-Ser349 |
Additional Info
| Function | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Plays a role in the senescence-associated cell size enlargement via SFK/PI3K/Rac1 and thus promotes senescent cell survival. Also participates in the innate immune response by acting as a ligand for the receptor TIGIT to inhibit NK-cell activity. |
| Protein Name | Nectin-4Ig Superfamily Receptor LnirNectin Cell Adhesion Molecule 4Poliovirus Receptor-Related Protein 4 |
| Database Links | Reactome: R-MMU-418990Reactome: -MMU-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionAdherens JunctionColocalizes With Afdn At Cadherin-Based Adherens Junctions |
| Alternative Protein Names | Nectin-4 proteinIg Superfamily Receptor Lnir proteinNectin Cell Adhesion Molecule 4 proteinPoliovirus Receptor-Related Protein 4 proteinNectin4 proteinLnir proteinPrr4 proteinPvrl4 protein |
Information sourced from Uniprot.org