Biotinylated Mouse CXADR protein (C-Avi-His) {Biotin} (STJP012864)
SPECIFICATIONS
HostMammalian Cells
ConjugationBiotin
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Biotinylated Mouse CXADR-C-Avi-His protein was developed from mammalian cells and has a target region of C-Avi-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8ยฐC for one week. Store at-20 to-80ยฐC for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/ยตg as determined by LAL test. |
Target Information
| Gene Symbol | Cxadr |
| Gene ID | 13052 |
| Uniprot ID | CXAR_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Leu20-Gly237 |
Additional Info
| Post Translational Modifications | Palmitoylated on Cys-259 and/or Cys-260.required for proper localization to the plasma membrane. |
| Function | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. |
| Protein Name | Coxsackievirus And Adenovirus Receptor HomologCarMcar |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-202733 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinBasolateral Cell MembraneCell JunctionTight JunctionAdherens JunctionIn Epithelial Cells Localizes To The Apical Junction Complex Composed Of Tight And Adherens JunctionsIn Airway Epithelial Cells Localized To Basolateral Membrane But Not To Apical SurfaceIsoform 3: Secreted |
| Alternative Protein Names | Coxsackievirus And Adenovirus Receptor Homolog proteinCar proteinMcar proteinCxadr proteinCar protein |
Information sourced from Uniprot.org