Biotinylated Human VTCN1/B7-H4 protein (C-Fc-Avi) {Biotin} (STJP012699)
SPECIFICATIONS
HostMammalian Cells
ConjugationBiotin
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Biotinylated Human VTCN1/B7-H4-C-Fc-Avi protein was developed from mammalian cells and has a target region of C-Fc-Avi. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | VTCN1 |
| Gene ID | 79679 |
| Uniprot ID | VTCN1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Phe29-Ala258 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. |
| Protein Name | V-Set Domain-Containing T-Cell Activation Inhibitor 1B7 Homolog 4B7-H4B7h.5Immune Costimulatory Protein B7-H4Protein B7s1T-Cell Costimulatory Molecule B7x |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinExpressed At The Cell SurfaceA Soluble Form Has Also Been Detected |
| Alternative Protein Names | V-Set Domain-Containing T-Cell Activation Inhibitor 1 proteinB7 Homolog 4 proteinB7-H4 proteinB7h.5 proteinImmune Costimulatory Protein B7-H4 proteinProtein B7s1 proteinT-Cell Costimulatory Molecule B7x proteinVTCN1 proteinB7H4 proteinUNQ659 proteinPRO1291 protein |
Information sourced from Uniprot.org