Biotinylated Human TIGIT protein (C-His-Avi) {Biotin} (STJP012691)

Name: Biotinylated Human TIGIT protein (C-His-Avi) {Biotin} (STJP012691)
SKU: STJP012691-100
Price: 1001.4 EUR
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationBiotin

ImmunogenHomo sapiens (Human)

STJP012691-100

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Short Description	Biotinylated Human TIGIT-C-His-Avi protein was developed from mammalian cells and has a target region of C-His-Avi. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Biotin
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Function	Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway. Also acts as a receptor for NECTIN4 to inhibit NK cell cytotoxicity.
Protein Name	T-Cell Immunoreceptor With Ig And Itim Domains V-Set And Immunoglobulin Domain-Containing Protein 9 V-Set And Transmembrane Domain-Containing Protein 3
Database Links
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Clustered To The Immunological Synapse Where It Disrupts Granule Polarization And Cytotoxicity Of Nk Cells Once Engaged With Pvr
Alternative Protein Names	T-Cell Immunoreceptor With Ig And Itim Domains protein V-Set And Immunoglobulin Domain-Containing Protein 9 protein V-Set And Transmembrane Domain-Containing Protein 3 protein TIGIT protein VSIG9 protein VSTM3 protein

Information sourced from Uniprot.org