Biotinylated Human CD28 protein (C-Fc-Avi) {Biotin} (STJP012460)

Name: Biotinylated Human CD28 protein (C-Fc-Avi) {Biotin} (STJP012460)
SKU: STJP012460-100
Price: 828.69 USD
Availability: InStock

⇓ Datasheet ⇓ SDS Citations

SPECIFICATIONS

HostMammalian Cells

ConjugationBiotin

ImmunogenHomo sapiens (Human)

STJP012460-100

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Short Description	Biotinylated Human CD28-C-Fc-Avi protein was developed from mammalian cells and has a target region of C-Fc-Avi. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Biotin
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a 0.22 Mu m filtered solution in 20m Tris-HCl, 150mM NaCl, pH 8.0.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Post Translational Modifications	Phosphorylated by LCK. Dephosphorylated by PTPN11. Isoform 3: Tyrosine phosphorylated induced by CD40LG.
Function	Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells. Isoform 3: Enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
Protein Name	T-Cell-Specific Surface Glycoprotein Cd28 Tp44 Cd Antigen Cd28
Database Links	Reactome: R-HSA-1257604 Reactome: R-HSA-164939 Reactome: R-HSA-2219530 Reactome: R-HSA-389356 Reactome: R-HSA-389357 Reactome: R-HSA-389359 Reactome: R-HSA-6811558
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Isoform 3: Cell Surface
Alternative Protein Names	T-Cell-Specific Surface Glycoprotein Cd28 protein Tp44 protein Cd Antigen Cd28 protein CD28 protein

Information sourced from Uniprot.org