ASXL3 Positive Control for STJ506012 peptide (STJ505773)
SPECIFICATIONS
ImmunogenPurified ZAP-70.
General Information
| Short Description | ASXL3 Positive Control for STJ506012 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Asxl3 |
| Gene ID | 211961 |
| Uniprot ID | ASXL3_MOUSE |
| Immunogen | Purified ZAP-70. |
| Specificity | This is positive control is recommended for use in combination with ASXL3 antibody STJ506012. |
Additional Info
| Function | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability. ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex and are essential for chromatin recruitment and transcriptional activation of associated genes. |
| Peptide Name | Putative Polycomb Group Protein Asxl3Additional Sex Combs-Like Protein 3 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Putative Polycomb Group Protein Asxl3 proteinAdditional Sex Combs-Like Protein 3 proteinAsxl3 protein |
Information sourced from Uniprot.org