Artemin protein (STJP000161)
SPECIFICATIONS
General Information
| Short Description | Artemin-protein was developed from. For use in research applications. |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/ml |
| Purification | Purified from serum-free CHO growth media by ion-exchange chromatography and gel-filtration. Protein is sterile-filtered through 0.22 ยตm filter |
| Formulation | 10 mM citrate; 150 mM NaCl pH 4.5 |
| Storage Instruction | Store at-70ยฐC upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
Target Information
| Gene Symbol | ARTN |
| Gene ID | 9048 |
| Uniprot ID | ARTN_HUMAN |
Additional Info
| Tissue Specificity | Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta, pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain. |
| Function | Growth factor that supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Acts by binding to its coreceptor, GFRA3, leading to autophosphorylation and activation of the RET receptor. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. |
| Protein Name | ArteminEnovinNeublastin |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Artemin proteinEnovin proteinNeublastin proteinARTN proteinEVN protein |
Information sourced from Uniprot.org