Aquaporin 7 Blocking Peptide is synthetically produced from the 150-200 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic amidated peptide taken within amino acid region 150-200 on rat Aquaporin 7 protein, covalently modified and conjugated to KLH.
Immunogen Region
150-200
Additional Info
Tissue Specificity
Detected in proximal tubules in kidney. Detected in the capillary network between muscle fibers in skeletal muscle and heart, and in spermatids and on spermatozoa tails in testis and epididymis. Detected in white and brown adipose tissue, especially on small blood vessels (at protein level). Detected in kidney and white adipose tissue.
Post Translational Modifications
Phosphorylation by PKA could prevent the interaction with PLIN1.
Function
Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea. Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels.
Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneLipid DropletInternalized From The Cell Membrane In Response To Catecholamine-Induced Activation Of PkaDetected On Intracellular Membranes And Colocalizes With Lipid DropletsColocalizes With Plin1 In AdipocytesProbably On Lipid Droplets
Alternative Peptide Names
Aquaporin-7 proteinAqp-7 proteinAquaglyceroporin-7 proteinAqp7 protein
