Aquaporin 2 Blocking Peptide is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 200-250 on human Aquaporin 2 protein.
Immunogen Region
200-250
Additional Info
Tissue Specificity
Detected in kidney, in cortical and the medullary collecting tubules (at protein level). Detected in kidney medulla and cortex.
Post Translational Modifications
Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent. N-glycosylated.
Function
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. Could also be permeable to glycerol.
Peptide Name
Aquaporin-2Aqp-2Adh Water ChannelAquaporin-CdAqp-CdCollecting Duct Water Channel ProteinWch-CdWater Channel Protein For Renal Collecting Duct
Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneCell MembraneCytoplasmic Vesicle MembraneGolgi ApparatusTrans-Golgi Network MembraneShuttles From Vesicles To The Apical MembraneVasopressin-Regulated Phosphorylation Is Required For Translocation To The Apical Cell MembranePlekha8/Fapp2 Is Required To Transport Aqp2 From The Tgn To Sites Where Aqp2 Is Phosphorylated
Alternative Peptide Names
Aquaporin-2 proteinAqp-2 proteinAdh Water Channel proteinAquaporin-Cd proteinAqp-Cd proteinCollecting Duct Water Channel Protein proteinWch-Cd proteinWater Channel Protein For Renal Collecting Duct proteinAqp2 protein
