Anti-ZP2 antibody [IE-3/CRL-2463] {APC} (STJA0029522)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationAPC
IsotypeIgG2a
General Information
| Short Description | Rat monoclonal Zona Pellucida Sperm-Binding Protein 2 antibody for use in FC, IF and WB in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/WB |
| Host | Rat |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | IE-3/CRL-2463 |
| Isotype | IgG2a |
| Conjugation | APC |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | Zp2 |
| Gene ID | 22787 |
| Uniprot ID | ZP2_MOUSE |
Additional Info
| Post Translational Modifications | Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos. N-glycosylated. O-glycosylated.contains sulfate-substituted glycans. |
| Function | Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. |
| Protein Name | Zona Pellucida Sperm-Binding Protein 2Zona Pellucida Glycoprotein 2Zp-2Zona Pellucida Protein A Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 2 |
| Database Links | Reactome: R-MMU-2534343 |
| Cellular Localisation | Processed Zona Pellucida Sperm-Binding Protein 2: Zona PellucidaCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Zona Pellucida Sperm-Binding Protein 2 antibodyAnti-Zona Pellucida Glycoprotein 2 antibodyAnti-Zp-2 antibodyAnti-Zona Pellucida Protein A Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 2 antibodyAnti-Zp2 antibodyAnti-Zp-2 antibodyAnti-Zpa antibody |
Information sourced from Uniprot.org