| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZP2 (651-745) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:4000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZP2 |
| Gene ID: |
7783 |
| Uniprot ID: |
ZP2_HUMAN |
| Immunogen Region: |
651-745 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 651-745 of human ZP2 (NP_003451.1). |
| Immunogen Sequence: |
KMTVSLPGPILLLSDDSSFR GVGSSDLKASGSSGEKSRSE TGEEVGSRGAMDTKGHKTAG DVGSKAVAAVAAFAGVVATL GFIYYLYEKRTVSNH |
| Tissue Specificity | Expressed in occytes(at protein level). |
| Post Translational Modifications | Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos. N-glycosylated. O-glycosylated.contains sulfate-substituted glycans. |
| Function | Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. |
| Protein Name | Zona Pellucida Sperm-Binding Protein 2Zona Pellucida Glycoprotein 2Zp-2Zona Pellucida Protein A Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 2 |
| Database Links | Reactome: R-HSA-2534343 |
| Cellular Localisation | Processed Zona Pellucida Sperm-Binding Protein 2: Zona PellucidaCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Zona Pellucida Sperm-Binding Protein 2 antibodyAnti-Zona Pellucida Glycoprotein 2 antibodyAnti-Zp-2 antibodyAnti-Zona Pellucida Protein A Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 2 antibodyAnti-ZP2 antibodyAnti-ZPA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
