Anti-ZNF683 antibody (420-524 aa) (STJ11107150)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZNF683 (420-524 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3 |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZNF683 |
| Gene ID | 257101 |
| Uniprot ID | ZN683_HUMAN |
| Immunogen Region | 420-524 aa |
| Immunogen Sequence | HSGARPFQCSVCRSRFTQHI HLKLHHRLHAPQPCGLVHTQ LPLASLACLAQWHQGALDLM AVASEKHMGYDIDEVKVSST SQGKARAVSLSSAGTPLVMG QDQNN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 420-524 of human ZNF683 (NP_001294854.1). |
Additional Info
| Tissue Specificity | Expressed in terminally differentiated effector CD8(+) T-cells, but not in naive and central memory cells. Expressed in terminally differentiated natural killer (NK) cells and natural killer (NKT) T-cells (at protein level). Expressed strongly in effector-type CD8(+) T-cells and weakly in naive and memory CD8(+) T-cells. Expressed in terminally differentiated natural killer (NK) cells. Isoform 2 is strongly expressed in effector CD8(+) T and natural killer (NK) cells. Isoform 1 is expressed in effector CD8(+) T and natural killer (NK) cells. (Microbial infection) Expressed in cytomegalovirus (CMV)-infected effector CD8(+) T-cells (at protein level). |
| Function | Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Also plays a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions. Isoform 1: Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T-cells. Isoform 2: Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells. |
| Protein Name | Tissue-Resident T-Cell Transcription Regulator Protein Znf683Homolog Of Blimp-1 In T-CellHobitZinc Finger Protein 683 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Tissue-Resident T-Cell Transcription Regulator Protein Znf683 antibodyAnti-Homolog Of Blimp-1 In T-Cell antibodyAnti-Hobit antibodyAnti-Zinc Finger Protein 683 antibodyAnti-ZNF683 antibody |
Information sourced from Uniprot.org