Anti-ZNF423 antibody (848-898 aa) (STJ195397)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ZN423 at the amino acid range 848-898
General Information
| Short Description | Rabbit polyclonal anti-Zinc finger protein 423 (848-898 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZNF423 |
| Gene ID | 23090 |
| Uniprot ID | ZN423_HUMAN |
| Immunogen | Synthesized peptide derived from the human ZN423 at the amino acid range 848-898 |
| Immunogen Region | 848-898 aa |
| Specificity | This antibody detects endogenous levels of ZN423 at Human/Mouse/Rat |
Additional Info
| Function | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation.this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. |
| Protein Name | Zinc Finger Protein 423Olf1/Ebf-Associated Zinc Finger ProteinHoazSmad- And Olf-Interacting Zinc Finger Protein |
| Database Links | Reactome: R-HSA-9844594 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein 423 antibodyAnti-Olf1/Ebf-Associated Zinc Finger Protein antibodyAnti-Hoaz antibodyAnti-Smad- And Olf-Interacting Zinc Finger Protein antibodyAnti-ZNF423 antibodyAnti-KIAA0760 antibodyAnti-NPHP14 antibodyAnti-OAZ antibody |
Information sourced from Uniprot.org