Anti-ZNF268 antibody (201-251 aa) (STJ193656)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ZN268 at the amino acid range 201-251
General Information
| Short Description | Rabbit polyclonal anti-Zinc finger protein 268 (201-251 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZNF268 |
| Gene ID | 10795 |
| Uniprot ID | ZN268_HUMAN |
| Immunogen | Synthesized peptide derived from the human ZN268 at the amino acid range 201-251 |
| Immunogen Region | 201-251 aa |
| Specificity | This antibody detects endogenous levels of ZN268 at Human |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-178 stabilizes the protein by interfering with its binding to TOLLIP, hence impairing its degradation by Tollip-mediated selective autophagy system. |
| Function | Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression. Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex. Involved in the regulation of antiviral interferon signaling. During viral infection, recruits SETD4 to TBK1, leading to TBK1 monomethylation, which is critical for the assembly of TBK1 complex and IRF3 signaling. |
| Protein Name | Zinc Finger Protein 268Zinc Finger Protein Hzf3 |
| Database Links | Reactome: R-HSA-212436 |
| Cellular Localisation | Isoform 1: NucleusIsoform 2: NucleusCytoplasmUnder Resting ConditionsDegraded By Autophagosomes In The CytosolResulting In Low Expression At The Protein LevelAccumulates In The Cytoplasm During Viral Infection |
| Alternative Antibody Names | Anti-Zinc Finger Protein 268 antibodyAnti-Zinc Finger Protein Hzf3 antibodyAnti-ZNF268 antibody |
Information sourced from Uniprot.org