| Tissue Specificity | Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells. |
| Post Translational Modifications | Phosphorylation at Ser-178 stabilizes the protein by interfering with its binding to TOLLIP, hence impairing its degradation by Tollip-mediated selective autophagy system. |
| Function | Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression. Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex. Involved in the regulation of antiviral interferon signaling. During viral infection, recruits SETD4 to TBK1, leading to TBK1 monomethylation, which is critical for the assembly of TBK1 complex and IRF3 signaling. |
| Protein Name | Zinc Finger Protein 268Zinc Finger Protein Hzf3 |
| Database Links | Reactome: R-HSA-212436 |
| Cellular Localisation | Isoform 1: NucleusIsoform 2: NucleusCytoplasmUnder Resting ConditionsDegraded By Autophagosomes In The CytosolResulting In Low Expression At The Protein LevelAccumulates In The Cytoplasm During Viral Infection |
| Alternative Antibody Names | Anti-Zinc Finger Protein 268 antibodyAnti-Zinc Finger Protein Hzf3 antibodyAnti-ZNF268 antibody |
Information sourced from Uniprot.org
