Anti-ZNF207 antibody (STJA0009271)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ZNF207
General Information
| Short Description | Rabbit polyclonal anti-BUB3-interacting and GLEBS motif-containing protein ZNF207 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZNF207 |
| Gene ID | 7756 |
| Uniprot ID | ZN207_HUMAN |
| Immunogen | Synthesized peptide derived from human ZNF207 |
| Specificity | This antibody detects endogenous levels of ZNF207 at Human |
Additional Info
| Function | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome. |
| Protein Name | Bub3-Interacting And Glebs Motif-Containing Protein Znf207BugzHbugzZinc Finger Protein 207 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreCytoplasmCytoskeletonSpindleLocalizes Primarily To The Nucleus In InterphaseConcentrates At Kinetochores Prior To Nuclear Envelope Breakdown And During Early PrometaphaseAnd Disappears From Kinetochores Upon Microtubule-Binding |
| Alternative Antibody Names | Anti-Bub3-Interacting And Glebs Motif-Containing Protein Znf207 antibodyAnti-Bugz antibodyAnti-Hbugz antibodyAnti-Zinc Finger Protein 207 antibodyAnti-ZNF207 antibodyAnti-BUGZ antibody |
Information sourced from Uniprot.org