Anti-ZNF143 antibody (437-638) (STJ119638)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZNF143 (437-638) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZNF143 |
| Gene ID | 7702 |
| Uniprot ID | ZN143_HUMAN |
| Immunogen Region | 437-638 |
| Immunogen Sequence | RTAHNDTEPIEEEQEAFFEP PPGQGEDVLKGSQITYVTGV EGDDVVSTQVATVTQSGLSQ QVTLISQDGTQHVNISQADM QAIGNTITMVTQDGTPITVP AHDAVISSAGTHSVAMVTAE GTEGEQVAIVAQDLAAFHTA SSEMGHQQHSHHLVTTETRP LTLVATSNGTQIAVQLGEQP SLEEAIRIASRIQQGETPGL DD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 437-638 of human ZNF143 (NP_003433.3). |
Additional Info
| Tissue Specificity | Expressed in all tissues tested, with the strongest expression in ovary. |
| Function | Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8. In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32. |
| Protein Name | Zinc Finger Protein 143Sph-Binding FactorSelenocysteine Trna Gene Transcription-Activating FactorHstaf |
| Database Links | Reactome: R-HSA-6807505Reactome: R-HSA-749476Reactome: R-HSA-76071 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein 143 antibodyAnti-Sph-Binding Factor antibodyAnti-Selenocysteine Trna Gene Transcription-Activating Factor antibodyAnti-Hstaf antibodyAnti-ZNF143 antibodyAnti-SBF antibodyAnti-STAF antibody |
Information sourced from Uniprot.org