Anti-ZMPSTE24 antibody (200-300) (STJ11100539)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZMPSTE24 (200-300) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZMPSTE24 |
| Gene ID | 10269 |
| Uniprot ID | FACE1_HUMAN |
| Immunogen Region | 200-300 |
| Immunogen Sequence | AWLFTLVVSLVLVTIYADYI APLFDKFTPLPEGKLKEEIE VMAKSIDFPLTKVYVVEGSK RSSHSNAYFYGFFKNKRIVL FDTLLEEYSVLNKDIQEDSG M |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ZMPSTE24 (NP_005848.2). |
Additional Info
| Tissue Specificity | Widely expressed. High levels in kidney, prostate, testis and ovary. |
| Function | Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum. Proteolytically removes the C-terminal three residues of farnesylated proteins. Also plays an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia. Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity. |
| Protein Name | Caax Prenyl Protease 1 HomologFarnesylated Proteins-Converting Enzyme 1Face-1Prenyl Protein-Specific Endoprotease 1Zinc Metalloproteinase Ste24 Homolog |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneEarly Endosome MembraneLate Endosome Membrane |
| Alternative Antibody Names | Anti-Caax Prenyl Protease 1 Homolog antibodyAnti-Farnesylated Proteins-Converting Enzyme 1 antibodyAnti-Face-1 antibodyAnti-Prenyl Protein-Specific Endoprotease 1 antibodyAnti-Zinc Metalloproteinase Ste24 Homolog antibodyAnti-ZMPSTE24 antibodyAnti-FACE1 antibodyAnti-STE24 antibody |
Information sourced from Uniprot.org