Anti-ZIC2 antibody (C-Term) (STJ72533)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ZIC2 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:1000.WB: In transfected RWPE1 transiently expressing Human ZIC2-Myc a band of approx. 65kDa is observed. This band is not observed in the non-transfected RWPE1, nor when GFP is transiently expre |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ZIC2 |
| Gene ID | 7546 |
| Uniprot ID | ZIC2_HUMAN |
| Accession Number | NP_009060.2 |
| Immunogen Region | C-Term |
| Immunogen Sequence | HSGLSSNFNEWY |
| Specificity | This antibody is expected to NOT cross-react with other ZIC proteins. |
Additional Info
| Function | Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. |
| Protein Name | Zinc Finger Protein Zic 2Zinc Finger Protein Of The Cerebellum 2 |
| Database Links | Reactome: R-HSA-9823739 |
| Cellular Localisation | NucleusCytoplasmLocalizes In The Cytoplasm In Presence Of Mdfic OverexpressionBoth Phosphorylated And Unphosphorylated Forms Are Localized In The Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein Zic 2 antibodyAnti-Zinc Finger Protein Of The Cerebellum 2 antibodyAnti-ZIC2 antibody |
Information sourced from Uniprot.org