Anti-ZFYVE9 antibody (1-260) (STJ111537)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZFYVE9 (1-260) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZFYVE9 |
| Gene ID | 9372 |
| Uniprot ID | ZFYV9_HUMAN |
| Immunogen Region | 1-260 |
| Immunogen Sequence | MENYFQAEAYNLDKVLDEFE QNEDETVSSTLLDTKWNKIL DPPSHRLSFNPTLASVNESA VSNESQPQLKVFSLAHSAPL TTEEEDHCANGQDCNLNPEI ATMWIDENAVAEDQLIKRNY SWDDQCSAVEVGEKKCGNLA CLPDEKNVLVVAVMHNCDKR TLQNDLQDCNNYNSQSLMDA FSCSLDNENRQTDQFSFSIN ESTEKDMNSEKQMDPLNRPK TEGRSVNHLCPTSSDSLAS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ZFYVE9 (NP_004790.2). |
Additional Info
| Tissue Specificity | Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes. |
| Function | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. |
| Protein Name | Zinc Finger Fyve Domain-Containing Protein 9Mothers Against Decapentaplegic Homolog-Interacting ProteinMadh-Interacting ProteinNovel Serine ProteaseNspReceptor Activation AnchorHsaraSmad Anchor For Receptor Activation |
| Database Links | Reactome: R-HSA-2173788 O95405-1Reactome: R-HSA-2173789 O95405-1Reactome: R-HSA-3304356 O95405-1Reactome: R-HSA-3656532 O95405-1 |
| Cellular Localisation | CytoplasmEarly Endosome Membrane |
| Alternative Antibody Names | Anti-Zinc Finger Fyve Domain-Containing Protein 9 antibodyAnti-Mothers Against Decapentaplegic Homolog-Interacting Protein antibodyAnti-Madh-Interacting Protein antibodyAnti-Novel Serine Protease antibodyAnti-Nsp antibodyAnti-Receptor Activation Anchor antibodyAnti-Hsara antibodyAnti-Smad Anchor For Receptor Activation antibodyAnti-ZFYVE9 antibodyAnti-MADHIP antibodyAnti-SARA antibodyAnti-SMADIP antibody |
Information sourced from Uniprot.org