| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZFYVE9 |
| Gene ID: | 9372 |
| Uniprot ID: | ZFYV9_HUMAN |
| Immunogen Region: | 1-260 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ZFYVE9 (NP_004790.2). |
| Immunogen Sequence: | MENYFQAEAYNLDKVLDEFE QNEDETVSSTLLDTKWNKIL DPPSHRLSFNPTLASVNESA VSNESQPQLKVFSLAHSAPL TTEEEDHCANGQDCNLNPEI ATMWIDENAVAEDQLIKRNY SWDDQCSAVEVGEKKCGNLA CLPDEKNVLVVAVMHNCDKR TLQNDLQDCNNYNSQSLMDA FSCSLDNENRQTDQFSFSIN ESTEKDMNSEKQMDPLNRPK TEGRSVNHLCPTSSDSLAS |
| Tissue Specificity | Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes. |
| Function | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. |
| Protein Name | Zinc Finger Fyve Domain-Containing Protein 9 Mothers Against Decapentaplegic Homolog-Interacting Protein Madh-Interacting Protein Novel Serine Protease Nsp Receptor Activation Anchor Hsara Smad Anchor For Receptor Activation |
| Database Links | Reactome: R-HSA-2173788 O95405-1 Reactome: R-HSA-2173789 O95405-1 Reactome: R-HSA-3304356 O95405-1 Reactome: R-HSA-3656532 O95405-1 |
| Cellular Localisation | Cytoplasm Early Endosome Membrane |
| Alternative Antibody Names | Anti-Zinc Finger Fyve Domain-Containing Protein 9 antibody Anti-Mothers Against Decapentaplegic Homolog-Interacting Protein antibody Anti-Madh-Interacting Protein antibody Anti-Novel Serine Protease antibody Anti-Nsp antibody Anti-Receptor Activation Anchor antibody Anti-Hsara antibody Anti-Smad Anchor For Receptor Activation antibody Anti-ZFYVE9 antibody Anti-MADHIP antibody Anti-SARA antibody Anti-SMADIP antibody |
Information sourced from Uniprot.org