Anti-ZEB2 antibody (1050-1214) (STJ29919)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZEB2 (1050-1214) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZEB2 |
| Gene ID | 9839 |
| Uniprot ID | ZEB2_HUMAN |
| Immunogen Region | 1050-1214 |
| Immunogen Sequence | SGEKPYQCDKCGKRFSHSGS YSQHMNHRYSYCKREAEERE AAEREAREKGHLEPTELLMN RAYLQSITPQGYSDSEERES MPRDGESEKEHEKEGEDGYG KLGRQDGDEEFEEEEEESEN KSMDTDPETIRDEEETGDHS MDDSSEDGKMETKSDHEEDN MEDGM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1050-1214 of human ZEB2 (NP_055610.1). |
Additional Info
| Post Translational Modifications | Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity. |
| Function | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2. |
| Protein Name | Zinc Finger E-Box-Binding Homeobox 2Smad-Interacting Protein 1Smadip1Zinc Finger Homeobox Protein 1b |
| Database Links | Reactome: R-HSA-9762293Reactome: R-HSA-9823739Reactome: R-HSA-9832991 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Zinc Finger E-Box-Binding Homeobox 2 antibodyAnti-Smad-Interacting Protein 1 antibodyAnti-Smadip1 antibodyAnti-Zinc Finger Homeobox Protein 1b antibodyAnti-ZEB2 antibodyAnti-KIAA0569 antibodyAnti-SIP1 antibodyAnti-ZFHX1B antibodyAnti-ZFX1B antibodyAnti-HRIHFB2411 antibody |
Information sourced from Uniprot.org