Anti-ZDHHC7 antibody (259-308 aa) (STJ92708)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ZDHHC7 at the amino acid range 259-308
General Information
| Short Description | Rabbit polyclonal anti-Palmitoyltransferase ZDHHC7 (259-308 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZDHHC7 |
| Gene ID | 55625 |
| Uniprot ID | ZDHC7_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ZDHHC7 at the amino acid range 259-308 |
| Immunogen Region | 259-308 aa |
| Specificity | DHHC-7 Polyclonal Antibody detects endogenous levels of DHHC-7 protein. |
Additional Info
| Function | Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones. Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways. Also functions in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane. In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation. Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration. Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane. In brain, could also palmitoylate SNAP25 and DLG4/PSD95. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Could also palmitoylate NCDN. May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells. Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD). |
| Protein Name | Palmitoyltransferase Zdhhc7Acyltransferase Zdhhc7Zinc Finger Dhhc Domain-Containing Protein 7Dhhc-7 |
| Database Links | Reactome: R-HSA-9009391 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc7 antibodyAnti-Acyltransferase Zdhhc7 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 7 antibodyAnti-Dhhc-7 antibodyAnti-ZDHHC7 antibody |
Information sourced from Uniprot.org