| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZDHHC17 (170-310) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZDHHC17 |
| Gene ID: |
23390 |
| Uniprot ID: |
ZDH17_HUMAN |
| Immunogen Region: |
170-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 170-310 of human ZDHHC17 (NP_056151.2). |
| Immunogen Sequence: |
TSIVAYLIAKGQDVDMMDQN GMTPLMWAAYRTHSVDPTRL LLTFNVSVNLGDKYHKNTAL HWAVLAGNTTVISLLLEAGA NVDAQNIKGESALDLAKQRK NVWMINHLQEARQAKGYDNP SFLRKLKADKEFRQKVMLGT P |
| Tissue Specificity | Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. |
| Post Translational Modifications | Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport. |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3. Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation. |
| Protein Name | Palmitoyltransferase Zdhhc17Acyltransferase Zdhhc17Dhhc Domain-Containing Cysteine-Rich Protein 17Dhhc17Huntingtin Yeast Partner HHuntingtin-Interacting Protein 14Hip-14Huntingtin-Interacting Protein 3Hip-3Huntingtin-Interacting Protein HPutative Mapk-Activating Protein Pm11Putative Nf-Kappa-B-Activating Protein 205Zinc Finger Dhhc Domain-Containing Protein 17 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembranePresynaptic Cell MembraneLow Extracellular Mg(2+) Induces Increase In Golgi And In Post-Golgi Membrane Vesicles |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc17 antibodyAnti-Acyltransferase Zdhhc17 antibodyAnti-Dhhc Domain-Containing Cysteine-Rich Protein 17 antibodyAnti-Dhhc17 antibodyAnti-Huntingtin Yeast Partner H antibodyAnti-Huntingtin-Interacting Protein 14 antibodyAnti-Hip-14 antibodyAnti-Huntingtin-Interacting Protein 3 antibodyAnti-Hip-3 antibodyAnti-Huntingtin-Interacting Protein H antibodyAnti-Putative Mapk-Activating Protein Pm11 antibodyAnti-Putative Nf-Kappa-B-Activating Protein 205 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 17 antibodyAnti-ZDHHC17 antibodyAnti-HIP14 antibodyAnti-HIP3 antibodyAnti-HYPH antibodyAnti-KIAA0946 antibodyAnti-HSPC294 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
