Anti-ZDHHC15 antibody (288-337 aa) (STJ92707)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ZDHHC15 at the amino acid range 288-337
General Information
| Short Description | Rabbit polyclonal anti-Palmitoyltransferase ZDHHC15 (288-337 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZDHHC15 |
| Gene ID | 158866 |
| Uniprot ID | ZDH15_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ZDHHC15 at the amino acid range 288-337 |
| Immunogen Region | 288-337 aa |
| Specificity | DHHC-15 Polyclonal Antibody detects endogenous levels of DHHC-15 protein. |
Additional Info
| Post Translational Modifications | Autopalmitoylated (in vitro). |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex. Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins. In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis. Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon. Could also catalyze the palmitoylation of GAP43. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Could also palmitoylate FYN as shown in vitro. May palmitoylate CALHM3 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics. |
| Protein Name | Palmitoyltransferase Zdhhc15Acyltransferase Zdhhc15Zinc Finger Dhhc Domain-Containing Protein 15Dhhc-15 |
| Database Links | |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinPostsynaptic Density |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc15 antibodyAnti-Acyltransferase Zdhhc15 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 15 antibodyAnti-Dhhc-15 antibodyAnti-ZDHHC15 antibodyAnti-UNQ1969 antibodyAnti-PRO4501 antibody |
Information sourced from Uniprot.org