Anti-ZC3H12D antibody (150-230) (STJ119890)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZC3H12D (150-230) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZC3H12D |
| Gene ID | 340152 |
| Uniprot ID | ZC12D_HUMAN |
| Immunogen Region | 150-230 |
| Immunogen Sequence | QHVLAELERQAVLVYTPSRK VHGKRLVCYDDRYIVKVAYE QDGVIVSNDNYRDLQSENPE WKWFIEQRLLMFSFVNDRFM P |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 150-230 of human ZC3H12D (NP_997243.2). |
Additional Info
| Tissue Specificity | Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines. |
| Function | May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages. Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation. |
| Protein Name | Probable Ribonuclease Zc3h12dMcp-Induced Protein 4Transformed Follicular LymphomaZinc Finger Ccch Domain-Containing Protein 12dP34 |
| Database Links | |
| Cellular Localisation | CytoplasmP-BodyColocalizes With Zc3h12a In Gw Bodies (Gwbs)Isoform 1: CytoplasmLocalized As Discrete GranulesColocalized With Mrna-Processing Body MarkersAgo2 And Dcp1aBut Not With A Stress Granule MakerTia1In The CytoplasmIsoform 3: CytoplasmNucleus |
| Alternative Antibody Names | Anti-Probable Ribonuclease Zc3h12d antibodyAnti-Mcp-Induced Protein 4 antibodyAnti-Transformed Follicular Lymphoma antibodyAnti-Zinc Finger Ccch Domain-Containing Protein 12d antibodyAnti-P34 antibodyAnti-ZC3H12D antibodyAnti-C6orf95 antibodyAnti-MCPIP4 antibodyAnti-TFL antibody |
Information sourced from Uniprot.org