Anti-ZBTB48 antibody (STJA0008074)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ZBTB48
General Information
| Short Description | Rabbit polyclonal anti-Telomere zinc finger-associated protein for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZBTB48 |
| Gene ID | 3104 |
| Uniprot ID | ZBT48_HUMAN |
| Immunogen | Synthesized peptide derived from human ZBTB48 |
| Specificity | This antibody detects endogenous levels of ZBTB48 at Human, Mouse |
Additional Info
| Function | Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression. In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 48Krueppel-Related Zinc Finger Protein 3Hkr3Telomere Zinc Finger-Associated ProteinTzapTelomere-Binding Protein And Transcriptional Activator Zbtb48Zinc Finger Protein 855 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeTelomereDirectly Binds The Telomeric Double-Stranded 5'-Ttaggg-3' RepeatAccording To A ReportPreferentially Binds To Long Telomeres That Have A Low Concentration Of Shelterin ComplexCompeting With The Telomeric Repeat Binding Factors Terf1 And Terf2According To Another ReportBinds Telomeres Regardless Of Their Length |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 48 antibodyAnti-Krueppel-Related Zinc Finger Protein 3 antibodyAnti-Hkr3 antibodyAnti-Telomere Zinc Finger-Associated Protein antibodyAnti-Tzap antibodyAnti-Telomere-Binding Protein And Transcriptional Activator Zbtb48 antibodyAnti-Zinc Finger Protein 855 antibodyAnti-ZBTB48 antibodyAnti-HKR3 antibodyAnti-TZAP antibodyAnti-ZNF855 antibody |
Information sourced from Uniprot.org