Anti-ZBTB48 antibody (1-280) (STJ29571)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZBTB48 (1-280) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZBTB48 |
| Gene ID | 3104 |
| Uniprot ID | ZBT48_HUMAN |
| Immunogen Region | 1-280 |
| Immunogen Sequence | MDGSFVQHSVRVLQELNKQR EKGQYCDATLDVGGLVFKAH WSVLACCSHFFQSLYGDGSG GSVVLPAGFAEIFGLLLDFF YTGHLALTSGNRDQVLLAAR ELRVPEAVELCQSFKPKTSV GQAAGGQSGLGPPASQNVNS HVKEPAGLEEEEVSRTLGLV PRDQEPRGSHSPQRPQLHSP AQSEGPSSLCGKLKQALKPC PLEDKKPEDCKVPPRPLEAE GAQLQGGSNEWEVVVQVED |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ZBTB48 (NP_005332.1). |
Additional Info
| Tissue Specificity | Detected in adrenal gland and neuroblastoma. |
| Function | Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression. In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 48Krueppel-Related Zinc Finger Protein 3Hkr3Telomere Zinc Finger-Associated ProteinTzapTelomere-Binding Protein And Transcriptional Activator Zbtb48Zinc Finger Protein 855 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeTelomereDirectly Binds The Telomeric Double-Stranded 5'-Ttaggg-3' RepeatAccording To A ReportPreferentially Binds To Long Telomeres That Have A Low Concentration Of Shelterin ComplexCompeting With The Telomeric Repeat Binding Factors Terf1 And Terf2According To Another ReportBinds Telomeres Regardless Of Their Length |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 48 antibodyAnti-Krueppel-Related Zinc Finger Protein 3 antibodyAnti-Hkr3 antibodyAnti-Telomere Zinc Finger-Associated Protein antibodyAnti-Tzap antibodyAnti-Telomere-Binding Protein And Transcriptional Activator Zbtb48 antibodyAnti-Zinc Finger Protein 855 antibodyAnti-ZBTB48 antibodyAnti-HKR3 antibodyAnti-TZAP antibodyAnti-ZNF855 antibody |
Information sourced from Uniprot.org