![Anti-ZAP-70 antibody [L453R+L453R] (STJ16101805)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/152311/347158/STJ16101805_1__29364.1681999433.jpg?c=1 "Anti-ZAP-70 antibody [L453R+L453R] (STJ16101805)")
![Anti-ZAP-70 antibody [L453R+L453R] (STJ16101805)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/152311/347158/STJ16101805_1__29364.1681999433.jpg?c=1 "Anti-ZAP-70 antibody [L453R+L453R] (STJ16101805)")
| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-ZAP-70 is suitable for use in Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | L453R+L453R |
| Conjugation: | Unconjugated |
| Isotype: | IgG2bk |
| Formulation: | PBS with sodium azide |
| Concentration: | >=449 mg/L |
| Dilution Range: | IHC-P 1:100 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Immunogen: | A prokaryotic recombinant protein corresponding to a portion of the N-terminus. |
| Background | ZAP-70 is a member of the syk family of proteins. It is expressed on T cells and NK cells and is required for the T cell receptor activation that triggers an immune response. CLL B cells that express the non-mutated immunoglobulin VH genes express levels of ZAP-70 protein that are comparable to those found in the blood T cells of healthy adults. Leukemic cells that express mutated Ig VH genes generally do not express detectable levels of ZAP-70 protein and this is correlated with the high level expression of CD38. |
Information sourced from Uniprot.org