Anti-BMP7 antibody (70-251) (STJ117995)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BMP7 (70-251) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BMP7 |
| Gene ID | 655 |
| Uniprot ID | BMP7_HUMAN |
| Immunogen Region | 70-251 |
| Immunogen Sequence | PHLQGKHNSAPMFMLDLYNA MAVEEGGGPGGQGFSYPYKA VFSTQGPPLASLQDSHFLTD ADMVMSFVNLVEHDKEFFHP RYHHREFRFDLSKIPEGEAV TAAEFRIYKDYIRERFDNET FRISVYQVLQEHLGRESDLF LLDSRTLWASEEGWLVFDIT ATSNHWVVNPRHNLGLQLSV ET |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 70-251 of BMP7 (NP_001710.1). |
Additional Info
| Tissue Specificity | Expressed in the kidney and bladder. Lower levels seen in the brain. |
| Post Translational Modifications | Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms. |
| Function | Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors. Promotes the expression of HAMP, this is repressed by its interaction with ERFE. |
| Protein Name | Bone Morphogenetic Protein 7Bmp-7Osteogenic Protein 1Op-1Eptotermin Alfa |
| Database Links | Reactome: R-HSA-2129379Reactome: R-HSA-9844594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 7 antibodyAnti-Bmp-7 antibodyAnti-Osteogenic Protein 1 antibodyAnti-Op-1 antibodyAnti-Eptotermin Alfa antibodyAnti-BMP7 antibodyAnti-OP1 antibody |
Information sourced from Uniprot.org