Anti-YWHAQ antibody (49-149) (STJ26144)

Name: Anti-YWHAQ antibody (49-149) (STJ26144)
SKU: STJ26144
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ26144

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Short Description	Rabbit polyclonal YWHAQ (49-149) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	YWHAQ
Gene ID	10971
Uniprot ID	1433T_HUMAN
Immunogen Region	49-149
Immunogen Sequence	KNVVGGRRSAWRVISSIEQK TDTSDKKLQLIKDYREKVES ELRSICTTVLELLDKYLIAN ATNPESKVFYLKMKGDYFRY LAEVACGDDRKQTIDNSQGA Y
Specificity	A synthetic peptide corresponding to a sequence within amino acids 49-149 of human 14-3-3 Theta (NP_006817.1).

Tissue Specificity	Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
Post Translational Modifications	Ser-232 is probably phosphorylated by CK1.
Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Protein Name	14-3-3 Protein Theta 14-3-3 Protein T-Cell 14-3-3 Protein Tau Protein Hs1
Database Links	Reactome: R-HSA-111447 Reactome: R-HSA-1445148 Reactome: R-HSA-5625740 Reactome: R-HSA-5628897 Reactome: R-HSA-75035 Reactome: R-HSA-9614399 Reactome: R-HSA-9735871 Reactome: R-HSA-9755779
Cellular Localisation	Cytoplasm In Neurons Axonally Transported To The Nerve Terminals
Alternative Antibody Names	Anti-14-3-3 Protein Theta antibody Anti-14-3-3 Protein T-Cell antibody Anti-14-3-3 Protein Tau antibody Anti-Protein Hs1 antibody Anti-YWHAQ antibody

Information sourced from Uniprot.org