Anti-YWHAB antibody (41-90 aa) (STJ91367)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human 14-3-3 beta at the amino acid range 41-90
General Information
| Short Description | Rabbit polyclonal anti-14-3-3 protein beta/alpha (41-90 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | YWHAB |
| Gene ID | 7529 |
| Uniprot ID | 1433B_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human 14-3-3 beta at the amino acid range 41-90 |
| Immunogen Region | 41-90 aa |
| Specificity | 14-3-3 Beta Polyclonal Antibody detects endogenous levels of 14-3-3 Beta protein. |
Additional Info
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. |
| Protein Name | 14-3-3 Protein Beta/AlphaProtein 1054Protein Kinase C Inhibitor Protein 1Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed |
| Database Links | Reactome: R-HSA-111447Reactome: R-HSA-1445148Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-170968Reactome: R-HSA-170984Reactome: R-HSA-2028269Reactome: R-HSA-392517Reactome: R-HSA-450385Reactome: R-HSA-450513Reactome: R-HSA-5625740Reactome: R-HSA-5628897Reactome: R-HSA-5673000Reactome: R-HSA-5674135Reactome: R-HSA-5675221Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-75035Reactome: R-HSA-9614399Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9726840Reactome: R-HSA-9726842Reactome: R-HSA-9735871Reactome: R-HSA-9755779Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvVacuole Membrane(Microbial Infection) Upon Infection With Chlamydia TrachomatisThis Protein Is Associated With The Pathogen-Containing Vacuole Membrane Where It Colocalizes With Incg |
| Alternative Antibody Names | Anti-14-3-3 Protein Beta/Alpha antibodyAnti-Protein 1054 antibodyAnti-Protein Kinase C Inhibitor Protein 1 antibodyAnti-Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed antibodyAnti-YWHAB antibody |
Information sourced from Uniprot.org