| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-3 5 RNA helicase YTHDC2 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
YTHDC2 |
| Gene ID: |
64848 |
| Uniprot ID: |
YTDC2_HUMAN |
| Specificity: |
This antibody detects endogenous levels of YTHDC2 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human YTHDC2 |
| Function | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis. |
| Protein Name | 3'-5' Rna Helicase Ythdc2Yth Domain-Containing Protein 2Hythdc2 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-3'-5' Rna Helicase Ythdc2 antibodyAnti-Yth Domain-Containing Protein 2 antibodyAnti-Hythdc2 antibodyAnti-YTHDC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunoprecipitation of YTHDC2 in 200 µg extracts from 293T cells using 0. 5 µg [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298). Western blot analysis was performed using [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298) at 1:1000 dilution.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/177942/369971/STJ11105298_1__81591.1713135883.jpg?c=1 "Immunoprecipitation of YTHDC2 in 200 µg extracts from 293T cells using 0. 5 µg [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298). Western blot analysis was performed using [KD Validated] YTHDC2 Rabbit polyclonal antibody (STJ11105298) at 1:1000 dilution.")
