Anti-YTHDC2 antibody (1131-1430) (STJ117201)

Name: Anti-YTHDC2 antibody (1131-1430) (STJ117201)
SKU: STJ117201
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⇓ Datasheet ⇓ SDS Citations

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ117201

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Short Description	Rabbit polyclonal YTHDC2 (1131-1430) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	YTHDC2
Gene ID	64848
Uniprot ID	YTDC2_HUMAN
Immunogen Region	1131-1430
Immunogen Sequence	HSLFLRRMRAPSKPWSQVDE ATIRAIIAVLSTEEQSAGLQ QPSGIGQRPRPMSSEELPLA SSWRSNNSRKSSADTEFSDE CTTAERVLMKSPSPALHPPQ KYKDRGILHPKRGTEDRSDQ SSLKSTDSSSYPSPCASPSP PSSGKGSKSPSPRPNMPVRY FIMKSSNLRNLEISQQKGIW STTPSNERKLNRAFWESSIV YLVFSVQGSGHFQGFSRMSS EIGREKSQDWGSAGLGGVF
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1131-1430 of human YTHDC2 (NP_073739.3).

Tissue Specificity	Expressed in testis. Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis.
Function	3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis.
Protein Name	3'-5' Rna Helicase Ythdc2 Yth Domain-Containing Protein 2 Hythdc2
Database Links
Cellular Localisation	Cytoplasm Perinuclear Region
Alternative Antibody Names	Anti-3'-5' Rna Helicase Ythdc2 antibody Anti-Yth Domain-Containing Protein 2 antibody Anti-Hythdc2 antibody Anti-YTHDC2 antibody

Information sourced from Uniprot.org