| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Ubiquitin Thioesterase Otu1 (249-348) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5008RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
YOD1 |
| Gene ID: |
55432 |
| Uniprot ID: |
OTU1_HUMAN |
| Immunogen Region: |
249-348 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 249-348 of human YOD1 (NP_061036.3). |
| Immunogen Sequence: |
FGEDAGYTKRVLLIYDGIHY DPLQRNFPDPDTPPLTIFSS NDDIVLVQALELADEARRRR QFTDVNRFTLRCMVCQKGLT GQAEAREHAKETGHTNFGEV |
| Function | Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation. |
| Protein Name | Ubiquitin Thioesterase Otu1Duba-8Hiv-1-Induced Protease 7Hin-7Hshin7Otu Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Antibody Names | Anti-Ubiquitin Thioesterase Otu1 antibodyAnti-Duba-8 antibodyAnti-Hiv-1-Induced Protease 7 antibodyAnti-Hin-7 antibodyAnti-Hshin7 antibodyAnti-Otu Domain-Containing Protein 2 antibodyAnti-YOD1 antibodyAnti-DUBA8 antibodyAnti-HIN7 antibodyAnti-OTUD2 antibodyAnti-PRO0907 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
