Anti-XRCC3 antibody (62-346) (STJ26131)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal XRCC3 (62-346) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | XRCC3 |
| Gene ID | 7517 |
| Uniprot ID | XRCC3_HUMAN |
| Immunogen Region | 62-346 |
| Immunogen Sequence | ILTALQLHQQKERFPTQHQR LSLGCPVLDALLRGGLPLDG ITELAGRSSAGKTQLALQLC LAVQFPRQHGGLEAGAVYIC TEDAFPHKRLQQLMAQQPRL RTDVPGELLQKLRFGSQIFI EHVADVDTLLECVNKKVPVL LSRGMARLVVIDSVAAPFRC EFDSQASAPRARHLQSLGAT LRELSSAFQSPVLCINQVTE AMEEQGAAHGPLGFWDERVS PALGITWANQLLVRLLADR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 62-346 of human XRCC3 (NP_001093588.1). |
Additional Info
| Function | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment.the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process.the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. |
| Protein Name | Dna Repair Protein Xrcc3X-Ray Repair Cross-Complementing Protein 3 |
| Database Links | Reactome: R-HSA-5685942Reactome: R-HSA-5693554Reactome: R-HSA-5693568Reactome: R-HSA-5693579 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionMitochondrionAccumulates In Discrete Nuclear Foci Prior To Dna DamageAnd These Foci Persist Throughout The Time Course Of Dna Repair |
| Alternative Antibody Names | Anti-Dna Repair Protein Xrcc3 antibodyAnti-X-Ray Repair Cross-Complementing Protein 3 antibodyAnti-XRCC3 antibody |
Information sourced from Uniprot.org