Anti-XPOT antibody (1-200) (STJ113944)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal XPOT (1-200) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | XPOT |
| Gene ID | 11260 |
| Uniprot ID | XPOT_HUMAN |
| Immunogen Region | 1-200 |
| Immunogen Sequence | MDEQALLGLNPNADSDFRQR ALAYFEQLKISPDAWQVCAE ALAQRTYSDDHVKFFCFQVL EHQVKYKYSELTTVQQQLIR ETLISWLQAQMLNPQPEKTF IRNKAAQVFALLFVTEYLTK WPKFFFDILSVVDLNPRGVD LYLRILMAIDSELVDRDVVH TSEEARRNTLIKDTMREQCI PNLVESWYQILQNYQFTNSE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human XPOT (NP_009166.2). |
Additional Info
| Function | Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Protein Name | Exportin-TExportin(TrnaTrna Exportin |
| Database Links | Reactome: R-HSA-6784531 |
| Cellular Localisation | NucleusCytoplasmNuclearOnce Bound To Trna And Ran The Complex Translocates To The CytoplasmShuttles Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Exportin-T antibodyAnti-Exportin(Trna antibodyAnti-Trna Exportin antibodyAnti-XPOT antibody |
Information sourced from Uniprot.org