Anti-XPNPEP3 antibody (STJA0009706)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human XPNPEP3
General Information
| Short Description | Rabbit polyclonal anti-Xaa-Pro aminopeptidase 3 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | XPNPEP3 |
| Gene ID | 63929 |
| Uniprot ID | XPP3_HUMAN |
| Immunogen | Synthesized peptide derived from human XPNPEP3 |
| Specificity | This antibody detects endogenous levels of XPNPEP3 at Human, Mouse, Rat |
Additional Info
| Function | Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Isoform 1: Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B.the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling. |
| Protein Name | Xaa-Pro Aminopeptidase 3X-Pro Aminopeptidase 3Aminopeptidase P3App3 |
| Database Links | |
| Cellular Localisation | Isoform 1: MitochondrionCytoplasmMainly MitochondrialTranslocates To The Cytoplasm Following Tnfrsf1b ActivationIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Xaa-Pro Aminopeptidase 3 antibodyAnti-X-Pro Aminopeptidase 3 antibodyAnti-Aminopeptidase P3 antibodyAnti-App3 antibodyAnti-XPNPEP3 antibody |
Information sourced from Uniprot.org