Anti-XIRP2 antibody (STJA0008113)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human XIRP2
General Information
| Short Description | Rabbit polyclonal anti-Xin actin-binding repeat-containing protein 2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | XIRP2 |
| Gene ID | 129446 |
| Uniprot ID | XIRP2_HUMAN |
| Immunogen | Synthesized peptide derived from human XIRP2 |
| Specificity | This antibody detects endogenous levels of XIRP2 at Human, Mouse, Rat |
Additional Info
| Function | Protects actin filaments from depolymerization. Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes. Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function. Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5. Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology. |
| Protein Name | Xin Actin-Binding Repeat-Containing Protein 2Beta-XinCardiomyopathy-Associated Protein 3Xeplin |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell JunctionColocalizes With Actin Stress Fibers |
| Alternative Antibody Names | Anti-Xin Actin-Binding Repeat-Containing Protein 2 antibodyAnti-Beta-Xin antibodyAnti-Cardiomyopathy-Associated Protein 3 antibodyAnti-Xeplin antibodyAnti-XIRP2 antibodyAnti-CMYA3 antibody |
Information sourced from Uniprot.org