Anti-xCT antibody (275-325) {FITC} (STJ506326)

SKU:
STJ506326-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-xCT (275-325) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: ELISA 1:10, 000
IP 1:200
WB 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLC7A11
Gene ID: 23657
Uniprot ID: XCT_HUMAN
Immunogen Region: 275-325
Immunogen: Synthetic peptide corresponding to amino acids within region 275-325 on human SLC7A11 protein.
Tissue Specificity Expressed in term placenta and primary term cytotrophoblast. Expressed mainly in the brain, but also in pancreas.
Post Translational Modifications Ubiquitinated by TRIM26.leading to proteasomal degradation.
Function Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress. The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine. In addition, mediates the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis. Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis. In vitro can also transport L-aspartate. May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons. Controls the production of pheomelanin pigment directly.
Protein Name Cystine/Glutamate Transporter
Amino Acid Transport System Xc-
Calcium Channel Blocker Resistance Protein Ccbr1
Solute Carrier Family 7 Member 11
Xct
Database Links Reactome: R-HSA-210991
Reactome: R-HSA-352230
Reactome: R-HSA-9818027
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Microvillus Membrane
Localized To The Microvillous Membrane Of The Placental Syncytiotrophoblast
Alternative Antibody Names Anti-Cystine/Glutamate Transporter antibody
Anti-Amino Acid Transport System Xc- antibody
Anti-Calcium Channel Blocker Resistance Protein Ccbr1 antibody
Anti-Solute Carrier Family 7 Member 11 antibody
Anti-Xct antibody
Anti-SLC7A11 antibody

Information sourced from Uniprot.org

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