Anti-Xanthine Oxidase antibody (1000-1100 aa) [SRM5096] (STJ11106879)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Xanthine Oxidase (1000-1100 aa) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5096 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
Target Information
| Gene Symbol | XDH |
| Gene ID | 7498 |
| Uniprot ID | XDH_HUMAN |
| Immunogen Region | 1000-1100 aa |
| Immunogen Sequence | CIIPTKFGISFTVPFLNQAG ALLHVYTDGSVLLTHGGTEM GQGLHTKMVQVASRALKIPT SKIYISETSTNTVPNTSPTA ASVSADLNGQAVYAACQTIL K |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Xanthine Oxidase (XDH). (NP_000370.2). |
Additional Info
| Tissue Specificity | Detected in milk (at protein level). |
| Post Translational Modifications | Subject to partial proteolysis.this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O). Contains sulfhydryl groups that are easily oxidized (in vitro).this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O). |
| Function | Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). |
| Protein Name | Xanthine Dehydrogenase/Oxidase Includes - Xanthine DehydrogenaseXd - Xanthine OxidaseXoXanthine OxidoreductaseXor |
| Database Links | Reactome: R-HSA-74259Reactome: R-HSA-8851680Reactome: R-HSA-9748787 |
| Cellular Localisation | CytoplasmPeroxisomeSecreted |
| Alternative Antibody Names | Anti-Xanthine Dehydrogenase/Oxidase Includes - Xanthine Dehydrogenase antibodyAnti-Xd - Xanthine Oxidase antibodyAnti-Xo antibodyAnti-Xanthine Oxidoreductase antibodyAnti-Xor antibodyAnti-XDH antibodyAnti-XDHA antibody |
Information sourced from Uniprot.org