| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WWP2 (1-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WWP2 |
| Gene ID: |
11060 |
| Uniprot ID: |
WWP2_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human WWP2 (NP_001257383.1). |
| Immunogen Sequence: |
MASASSSRAGVALPFEKSQL TLKVVSAKPKVHNRQPRINS YVEVAVDGLPSETKKTGKRI GSSELLWNEIIILNVTAQSH LDLKVWSCHTLRNELLGTAS VNLSNVLKNNGGKMENMQLT LNLQTENKGSVVSGGELTIF LDGPTVDLGNVPNGSALTDG SQLPSRDSSGTAVAPENRHQ PPSTNCFGGRSRTHRHSGAS ARTTPATGEQSPGARSRHRQ PVKNSGHSGLANGTVNDEP |
| Tissue Specificity | Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. Also detected in spleen and peripheral blood leukocytes. |
| Post Translational Modifications | Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation.in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation.in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2.the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. |
| Protein Name | Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp2Atrophin-1-Interacting Protein 2Aip2Hect-Type E3 Ubiquitin Transferase Wwp2Ww Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-8948751Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9013420Reactome: R-HSA-9013507 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp2 antibodyAnti-Atrophin-1-Interacting Protein 2 antibodyAnti-Aip2 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Wwp2 antibodyAnti-Ww Domain-Containing Protein 2 antibodyAnti-WWP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
