Anti-WWOX antibody [R02-0E3] (STJA0035405)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human WWOX
General Information
| Short Description | Rabbit monoclonal anti-WWOX for use in WB, IHC-P and IP in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-0E3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | WWOX |
| Gene ID | 51741 |
| Uniprot ID | WWOX_HUMAN |
| Immunogen | Recombinant protein of human WWOX |
Additional Info
| Tissue Specificity | Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. |
| Post Translational Modifications | Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation. Ubiquitinated when phosphorylated by TNK2, leading to its degradation. |
| Function | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. |
| Protein Name | Ww Domain-Containing OxidoreductaseFragile Site Fra16d OxidoreductaseShort Chain Dehydrogenase/Reductase Family 41c Member 1 |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-8866904Reactome: R-HSA-8866907 |
| Cellular Localisation | CytoplasmNucleusMitochondrionGolgi ApparatusLysosomePartially Localizes To The MitochondriaTranslocates To The Nucleus Upon Genotoxic Stress Or Tnf StimulationTranslocates To The Nucleus In Response To Tgfb1Isoform 5 And Isoform 6 May Localize In The NucleusLocalized To The Lysosome Probably Upon Binding To Vopp1 |
| Alternative Antibody Names | Anti-Ww Domain-Containing Oxidoreductase antibodyAnti-Fragile Site Fra16d Oxidoreductase antibodyAnti-Short Chain Dehydrogenase/Reductase Family 41c Member 1 antibodyAnti-WWOX antibodyAnti-FOR antibodyAnti-SDR41C1 antibodyAnti-WOX1 antibody |
Information sourced from Uniprot.org