Anti-WTAP antibody [R09-9D8] (STJA0033812)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human WTAP
General Information
| Short Description | Rabbit monoclonal anti-WTAP for use in WB, IHC-P and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R09-9D8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | WTAP |
| Gene ID | 9589 |
| Uniprot ID | FL2D_HUMAN |
| Immunogen | Recombinant protein of human WTAP |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. |
| Protein Name | Pre-Mrna-Splicing Regulator WtapFemale-Lethal(2d HomologHfl(2dWt1-Associated ProteinWilms Tumor 1-Associating Protein |
| Database Links | Reactome: R-HSA-72203 |
| Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmCytoplasmMainly Nuclear With Some Fraction Located In The CytoplasmZc3h13 Is Required To Anchor Component Of The Macom SubcomplexSuch As VirmaIn The Nucleus |
| Alternative Antibody Names | Anti-Pre-Mrna-Splicing Regulator Wtap antibodyAnti-Female-Lethal(2d Homolog antibodyAnti-Hfl(2d antibodyAnti-Wt1-Associated Protein antibodyAnti-Wilms Tumor 1-Associating Protein antibodyAnti-WTAP antibodyAnti-KIAA0105 antibody |
Information sourced from Uniprot.org